Fig. 8. Quantitative clonal analysis of Numb-infected and control retinal explants. Newborn explants were infected and analyzed as in Fig. 7. A total of 1891 control clones and 1704 Numb clones in nine different retinal explants were analyzed. The results are shown as mean±s.d. (A) Clone size. (B) Proportion of photoreceptor-only clones. (C) Proportion of photoreceptors in the total population of infected cells analyzed. (D) Proportion of clones containing at least one neuron, one Müller cell or more than one cell type. (E) Proportion of interneurons or Müller cells in the total population of infected cells analyzed. (F) Proportion of two-cell clones containing either two photoreceptors (PR) or a photoreceptor and another cell type. In (B-F), all of the differences between the control and Numb clones are significantly different when analyzed by a non-parametric statistical test (P<0.01).

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