Fig. 2. Alterations in hair follicles and tooth germs in p107/p130 knockout mice. Hematoxylin/Eosin skin sections of wild type (A-C) and 107/130 null (A'-C') 18.5 dpc (A,A') and 14.5 dpc (B,B') embryos showing the decrease in hair germs (see arrows). Snout of wild-type (C) and 107/130 null (C') 14.5 dpc embryos showed a developmental delay of the whiskers. (D) Quantitative analysis of the number of hair follicles in the skin of 18.5 and 16.5 dpc embryos. (E) Analysis of the developmental stage of hair follicles in 18.5 dpc embryos. Data in D and E come from the quantification of three different sections of at least three different animals and are shown as mean±s.d. The hair follicle stages are as reported (Muller-Rover et al., 2001; Paus et al., 1999). Hematoxylin/Eosin medial sections from the heads of wild type (F,G) and 107/130 null (F',G') 18.5 dpc embryos. A few 107/130-null embryos showed anodontia with the presence of undifferentiated mesenchimal tissue in the site of incisors (compare arrows in F' with those in F). When present, tooth germ in 107/130-null embryos displayed variable degrees of microdontia associated with hypoplasia and disorganization of the odontoblast layer (compare arrows in G' with those in G). pu, dental pulp; od, odontoblast layer; de, dentine; am, ameloblast layer; ep, enamel pulp. Scale bars: 100 µm in A,C,C',G,G'; 50 µm in B,B'; 500 µm in F,F'.

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