Fig. 4. The ak mice have impaired spontaneous locomotor activity. (A) Spontaneous ambulatory activity of mice recorded over 23 hours. The distance (cm) covered during each 1 hour period is shown for wild-type and ak mice. (B) Average distance covered per hour for wild-type and ak mice during daytime and night-time. (C) Average ambulatory time spent per hour for the recordings shown in E during daytime and night-time. (D) Spontaneous stereotypic movements of mice recorded over 23 hours. The stereotypic movements during each 1 hour period are shown for wild-type and ak mice. (E) Average numbers of stereotypic movements per hour for wild-type and ak mice during daytime and night-time. (F) Average time spent making stereotypic movements per hour for the recordings shown in H during daytime and night-time. (G) Resting time of mice recorded over 23 hours. The resting time during each 1 hour period is shown for wild-type and ak mice. (H) Average resting time per hour for wild-type and ak mice during daytime and night-time. (I) Average speed of spontaneous ambulatory movements for wild-type and ak mice during daytime and night-time. All locomotor activity data are represented as the mean ± s.e.m. (n=5). Locomotor activity scores for ak mice that are significantly different from wild-type scores are marked with a asterisk (P<0.01, t-test).

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