Fig. 3. Effects of the foxi one mutation on otic placode markers. Right panels, foo/foo homozygote embryos; left panels, same-clutch wild-type siblings. (A,B) Lateral view of pax8 expression in wild-type (A) and foo/foo (B) one-somite stage embryos. Arrows indicate otic placode region. Arrowhead (B) indicates normal presumptive kidney staining. (C,D) Lateral view of dlx3b staining in one-somite stage wild-type (C) and a foo/foo (D) embryos. Note only otic placode expression is altered in the mutant. (E,F) dlx3b staining in 10-somite stage wild-type (E) and foo/foo (F) embryos. Arrow in E indicates otic placode. Arrows in F indicate scattered staining. (G,H) pax2a expression in 10-somite stage wild-type (G) and foo/foo (H). Arrows indicate scattered otic placode expression in mutant. Arrowheads indicate normal mid-hindbrain boundary and eye expression.

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