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Fig. 3. (A) RNA expression profile of upregulated genes in skin of untreated (0d)
and treated (1d and 4d) transgenic and wild-type mice. (B,C) Immunolabeling of
4 days OHT-treated skin with antibodies to the proteins indicated. Scale bars:
10 µm (B), 5 µm (C). (D) In situ hybridisation of BSSP using
radiolabelled RNA antisense probes (BSSP-as), comparing wild-type (wt) and
transgenic (tg) skin untreated (0d) or harvested 1 day or 4 days (1d, 4d)
after OHT treatment. A ß-actin probe served as positive control and a
BSSP sense probe (BSSP-s) as negative control. The arrowheads indicate the
expression of BSSP mRNA in sebaceous glands in untreated transgenic mice
(tg-0d) and in the interfollicular epidermis of transgenic mice treated with
OHT for 4 days (tg-4d). Scale bar: 10 µm
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