Fig. 5. Myc activation delays epidermal wound healing in vivo and in vitro. (A) Three days after wounding wild-type and transgenic mice received daily OHT treatment for 4 days. Wounds of wild-type mice had completely re-epithelialised, but wounds of transgenic mice remained open. Arrowheads indicate wound edges. Ki67 labelling of wound margins is shown in right-hand panels. Scale bar: 100 µm. (B) Wounds were made in sheets of cultured human keratinocytes (0h) and monitored after 24 or 48 hours. Myc over-expressing keratinocytes (Kq-MycER) were compared to controls (Kq-pBP). Cells were stained with phalloidin. Scale bar: 10 µm.

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