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Fig. 7. Myc activation did not disrupt cell-cell adhesion or focal adhesions, but
did decrease hemidesmosome formation. (A) Cultured human keratinocytes
(Kq-MycER, Kq-106ER, Kq-pBP) were stained with antibodies to the proteins
shown. Nuclei are stained for Myc using 9E10 antibody. (B) Flow cytometry of
primary keratinocytes isolated from transgenic or wild-type mice 2 days after
OHT treatment using antibodies against the ß1 and 
6 integrin
subunits and CD98. (C) Real-time PCR determination of 6 integrin
subunit mRNA levels in transgenic (tg) mice untreated (0d) or treated with OHT
for 4 days (4d) (P<0.01).
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