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Strabismus functions in planar polarity

Planar cell polarity (PCP) studies in the fly have identified several key proteins, such as Strabismus (Stbm), that are required for planar polarity decisions and act by forming asymmetrically localized complexes. In a study of how Stbm functions in this process, Bastock et al. now show, on p. 3007, that Stbm localizes preferentially to the proximal edge of wing cells in the adherens junction zone where other PCP proteins, such as Dishevelled (Dsh) and Prickle (Pk), also localize. Here, Stbm binds directly to Dsh and Pk to recruit them to cell membranes – in its absence, both proteins become mislocalized. In a two-step model, the authors propose that Stbm acts with Frizzled and Flamingo to apicolaterally localize other PCP proteins, including Dsh and Pk. Dsh and Pk then mediate the asymmetric localization of these proteins to the proximal-distal axis.

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Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning

Rebecca Bastock, Helen Strutt, and David Strutt
Development 2003 130: 3007-3014. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?