QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

New Hh targets in the eye

In the Drosophila eye, loss of Hh signalling blocks the initiation of photoreceptor morphogenesis, but how this comes about is poorly understood. Using loss- and gain-of-function genetics, Graeme Mardon and colleagues have now discovered that the principal role of Hh signalling in Drosophila eye development is to alleviate the repression of two key genes that function in a retinal determination network – dpp and eya. Hh signalling does this, they propose on p. 3053, by blocking the cleavage of the active form of Cubitus interruptus, a Hh pathway component, into its repressive form, which represses dpp. Once dpp expression is established, it acts with another gene, ey, to initiate eya expression, in a vital step towards establishing the retinal determination network. Importantly, Hh acts here not as a classical morphogen but as a binary switch that initiates photoreceptor differentiation.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Mechanism of hedgehog signaling during Drosophila eye development

Kartik S. Pappu, Rui Chen, Brooke W. Middlebrooks, Catherine Woo, Ulrike Heberlein, and Graeme Mardon
Development 2003 130: 3053-3062. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?