Fig. 7. Loss of optic disc astrocyte precursor cells in ThyCreShh^n/c mice is not caused by a global defect in proliferation. Ntn1 (A,D), Pax2 (B,E) and Pdgfra (C,F) transcript expression detected by in situ hybridization in sections through the optic disc of wild-type (A-C) and ThyCreShh^n/c (D-F) embryos, at E12 (A,D) and E17 (B,C,E,F). Compared with wild-type mice (A-C), there was no Ntn1 (D), Pax2 (E) or Pdgfra (F) expression in optic discs of ThyCreShh^n/c-mutant mice. Pax2 (G,H) and Pdgfra (I,J) expression is comparable between E18 wild-type (G,I) and cyclin D1^-/- (H,J) mice.

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