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New insights into dauer development

The dauer stage of C. elegans development has been well studied to uncover how environmental signals regulate developmental fates. Dauer formation is regulated by three signalling pathways, which the nuclear hormone receptor DAF-12 integrates. On p. 3237, Ohkura et al. report a new dauer-like mutant, sdf-9, that resembles the daf-12 and daf-9 dauer mutants. By mosaic analysis, the authors show that sdf-9, which encodes a tyrosine phosphatase-like molecule, is expressed in two mysterious cells in the head, XXXL/R, which also express daf-9 and npc-1. (DAF-9 is involved in synthesizing the ligand of DAF-12 and NPC-1 functions in intracellular sterol transport.) Because ablating these cells reproduces the phenotype of the sdf-9 mutant, the authors propose that they might play a key role in metabolizing a steroid hormone ligand for DAF-12 through the functions of DAF-9 and SDF-9.

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Related articles in Development:

SDF-9, a protein tyrosine phosphatase-like molecule, regulates the L3/dauer developmental decision through hormonal signaling in C. elegans

Kiyotaka Ohkura, Norio Suzuki, Takeshi Ishihara, and Isao Katsura
Development 2003 130: 3237-3248. [Abstract] [Full Text]  

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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?