Fig. 5. Sall1, Eya1 and Six1 expression is not affected in Pax2^-/- metanephric mesenchyme (mm). (A,B) Sall1 is expressed in the metanephric mesenchyme and its expression is not affected in Pax2^-/- mesenchyme at E10.5. (C,D) Eya1 is expressed in the metanephric mesenchyme and its expression level is unaffected in Pax2^-/- embryos at E10.5. (E,F) Six1 is expressed in the metanephric mesenchyme and its expression level is also unaffected in Pax2^-/- embryos at E10.5. (G,H) However, Six1 expression in Eya1^-/- mesenchyme is significantly reduced when compared to that in wild-type embryos at E10.5. Its expression in the limb bud and somites is also significantly reduced. Six homozygous embryos were used for each probe.

Return to article