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Fig. 1. Cloning of unc-71. (A) unc-71 corresponds to
Y37D8A.13/adm-1. Rescue of unc-71 pleiotropies: movement
(Unc); egg-laying (Egl); and axon morphology of the D neurons (Max). +,
rescue;–no rescue; *, the unc-71 minigene NH#1092
was used for these experiments. (B) UNC-71 domain structures. UNC-71 contains
an inactive metalloprotease domain. A consensus active zinc-binding catalytic
site sequence is shown for comparison. The underlined residues are required
for zinc binding. The conserved residues in the disintegrin loop are
highlighted in red, and lesions of two unc-71 mutations are shown
above. The positions of other unc-71 mutations are indicated as
color-coded bars.
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