Fig. 4. Genetic interactions of unc-71 with ADAMs, integrins, unc-6 and other signaling molecules. (A) unc-71 acts independently of the other three C. elegans ADAMs. Percentages of dorsal guidance defects were quantified as Table 4. (B) Axonal fasciculation defects in unc-71 were strongly enhanced by mutations in ina-1 and pat-3 but not inb-1. The percentages of fasciculation defects were quantified by counting the number of ventral cord processes from VD_3-12 that were separated from the DD ventral cord processes, divided by 10. (C) Axonal defects in double mutants of unc-71 with mutants in the unc-6/netrin signaling pathway. Percentages of dorsal guidance defects were quantified as Table 4. Bars represent standard deviation. ^*P<0.001, Student's t-test, compared with unc-71 single mutant control. ^**P>0.05, Student's t-test, compared with unc-71 single mutant control.

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