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Fig. 4. The Dishevelled-dependent WNT/PCP pathway is not required for GATA4-mediated cardiogenesis. Injection of Dishevelled (Dsh) {delta}PDZ dominant-negative construct, which inhibits both canonical and PCP WNT pathways, does not alter induction of the cardiac marker MLC2 by GATA4 and Cerberus. Similarly, Dishevelled DEP+, a PCP pathway-specific dominant-negative construct, does not affect induction of MLC2 by GATA4.





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