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First published online July 21, 2003

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Six1 and ear development

Mammalian inner ear development begins with the induction of the otic placode, an ectodermal thickening on either side of the hindbrain. Placode invagination forms the otic vesicle, which differentiates into the inner ear. Many genes are involved in this developmental program but their function during inner ear morphogenesis is poorly understood. On p. 3989, Zheng et al. investigate the role of the mammalian homeobox gene Six1 in auditory system development. They report that Six1 is expressed in all the sensory epithelia of the developing ear in normal mice. By examining auditory system development in Six1^-/- mice, they also show that Six1, similar to Eya1, is not required for initiation of inner ear organogenesis but rather regulates important signalling molecules (including Fgf3, Fgf10 and Bmp4) that are involved in the specification of the inner ear sensory organs.

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Related articles in Development:

The role of Six1 in mammalian auditory system development

Weiming Zheng, Li Huang, Zhu-Bo Wei, Derek Silvius, Bihui Tang, and Pin-Xian Xu
Development 2003 130: 3989-4000. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?