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First published online July 21, 2003

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A lucky break: bone development reactivated

Bone repair after injury seems to closely resemble embryonic bone development: for example, both processes involve progenitor cell recruitment, vascular network establishment and the differentiation of precursor cells into bone or cartilage. But just how similar are the two processes? To find out, Colnot et al. (see p. 4123) examined fracture repair in the absence of matrix metalloproteinase 9 (MMP9), a key regulator of bone development. They report that the skeletal defects that occur during bone repair in adult Mmp9^-/- mice are very similar to those that occur during bone development in these mutants and that, as in development, MMP9 mediates the vascularisation of hypertrophic cartilage. These parallels between endochondral bone formation during development and fracture repair strongly indicate that the embryonic bone differentiation program is reactivated during adult fracture repair.

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Related articles in Development:

Altered fracture repair in the absence of MMP9

Céline Colnot, Zachary Thompson, Theodore Miclau, Zena Werb, and Jill A. Helms
Development 2003 130: 4123-4133. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?