Fig. 3. Expression of midline markers is affected in Msx1^-/- mutant embryos. E11.5 wild-type (A,C) and mutant (B,D) embryos were whole-mount hybridized with a Bmp6 (A,B) or a Wnt1 (C,D) probe. Arrowheads in A,B indicate the Bmp6 expression domains in the telencephalic choroid plexus. (E,F) Transverse sections across P1 of E12.5 embryos hybridized with a Pax6 probe. In the mutant, the Pax6 expression domain extends over the midline (F, arrow) from which it is normally excluded (E, arrow)). In A-D, anterior is towards the right. m, mesencephalon; P1, prosomere 1; t, telencephalon; Wt, wild type; -/-, Msx1^-/- homozygous mutant.

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