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First published online August 4, 2003

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Development 130, e1801 (2003)
Copyright © 2003 The Company of Biologists Limited

IN THIS ISSUE

Maternal Ezh2 required for early mouse development


Heritable epigenetic control of gene expression is essential for the early development of most organisms. One protein involved in this process is enhancer of zeste 2 (Ezh2), which is maternally inherited, contains a conserved SET domain and is involved in methylating lysine residues on histone tails. To investigate the role of Ezh2 in early mouse development, Erhardt et al. used a conditional Ezh2 allele to deplete oocytes of maternal Ezh2 (see p. 4235). Even though embryonic transcription of Ezh2 occurred as early as the four-cell stage, loss of maternal Ezh2 resulted in severely retarded foetal and neonatal growth. The authors attribute this effect to the disruption of the asymmetry in histone methylation that is normally established in the zygote by maternal Ezh2. They also report that maternal Ezh2 is required for crucial epigenetic changes in trophectoderm and epiblast cells.


Related articles in Development:

Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development
Sylvia Erhardt, I-hsin Su, Robert Schneider, Sheila Barton, Andrew J. Bannister, Laura Perez-Burgos, Thomas Jenuwein, Tony Kouzarides, Alexander Tarakhovsky, and M. Azim Surani
Development 2003 130: 4235-4248. [Abstract] [Full Text]  




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