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First published online August 4, 2003

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Germ cell migration: signalling the way

Gonad development usually involves the migration of primordial germ cells (PGCs) to the eventual site of gamete production. In zebrafish, this migration requires a signalling system comprising stromal cell-derived factor 1 (SDF1) and the G-protein coupled receptor CXCR4. On p. 4279, Molyneaux and colleagues have investigated whether PGC migration mechanisms are conserved between zebrafish and mice; they report that mice share many of the same requirements. For example, in cultured mouse embryos, exogenous SDF1 diverted PGCs from their normal route from the gut to the genital ridge. Similarly, in Cxcr4^-/- embryos, germ cells did not colonise the genital ridge normally. However, Cxcr4^-/- mouse germ cells still migrated from the primitive streak to the gut, whereas in zebrafish, SDF1-CXCR4 signalling is needed for this stage of migration.

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The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival

Kathleen A. Molyneaux, Hélène Zinszner, Prabhat S. Kunwar, Kyle Schaible, Jürg Stebler, Mary Jean Sunshine, William O'Brien, Erez Raz, Dan Littman, Chris Wylie, and Ruth Lehmann
Development 2003 130: 4279-4286. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?