QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online August 4, 2003

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Search for Related Content

Kekkon 1: from development to cancer therapy?

Signalling through the Drosophila EGF receptor (DER), which is involved in several developmental processes, is controlled by activating and inhibiting ligands. On p. 4483, Ghiglione et al. examine how one inhibitor, Kekkon 1 (Kek1), achieves the negative feedback control of DER that occurs during Drosophila oogenesis and imaginal disc development. Their structure-function analyses show that the extracellular, leucine-rich repeat domains of Kek1 are needed for the in vivo association of Kek1 and DER as a heterodimer. Their findings also show that, in mammalian cell-based assays, the interaction of Kek1 with mammalian ErbB growth factor receptor tyrosine kinases blocks activating ligands from binding these receptors, as well as blocking their autophosphorylation and subsequent signal transduction. Given the overexpression of some of these receptors in human tumours, Ghiglione et al. suggest that Kek1 or its unknown mammalian homologues might have clinical utility as anti-tumour agents.

Related articles in Development:

Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1

Christian Ghiglione, Laufey Amundadottir, Margret Andresdottir, David Bilder, John A. Diamonti, Stéphane Noselli, Norbert Perrimon, and Kermit L. Carraway III
Development 2003 130: 4483-4493. [Abstract] [Full Text]  

This article has been cited by other articles:

				A. Ghosh-Roy, B. S. Desai, and K. Ray Dynein Light Chain 1 Regulates Dynamin-mediated F-Actin Assembly during Sperm Individualization in Drosophila Mol. Biol. Cell, July 1, 2005; 16(7): 3107 - 3116. [Abstract] [Full Text] [PDF]

				M. J. Laviolette, P. Nunes, J.-B. Peyre, T. Aigaki, and B. A. Stewart A Genetic Screen for Suppressors of Drosophila NSF2 Neuromuscular Junction Overgrowth Genetics, June 1, 2005; 170(2): 779 - 792. [Abstract] [Full Text] [PDF]

				E. A. Sevrioukov, N. Moghrabi, M. Kuhn, and H. Kramer A Mutation in dVps28 Reveals a Link between a Subunit of the Endosomal Sorting Complex Required for Transport-I Complex and the Actin Cytoskeleton in Drosophila Mol. Biol. Cell, May 1, 2005; 16(5): 2301 - 2312. [Abstract] [Full Text] [PDF]

				J. D. Baker, S. Adhikarakunnathu, and M. J. Kernan Mechanosensory-defective, male-sterile unc mutants identify a novel basal body protein required for ciliogenesis in Drosophila Development, July 15, 2004; 131(14): 3411 - 3422. [Abstract] [Full Text] [PDF]

				M.-g. Li, M. Serr, E. A. Newman, and T. S. Hays The Drosophila tctex-1 Light Chain Is Dispensable for Essential Cytoplasmic Dynein Functions but Is Required during Spermatid Differentiation Mol. Biol. Cell, July 1, 2004; 15(7): 3005 - 3014. [Abstract] [Full Text] [PDF]

				A. Ghosh-Roy, M. Kulkarni, V. Kumar, S. Shirolikar, and K. Ray Cytoplasmic Dynein-Dynactin Complex Is Required for Spermatid Growth but Not Axoneme Assembly in Drosophila Mol. Biol. Cell, May 1, 2004; 15(5): 2470 - 2483. [Abstract] [Full Text] [PDF]

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Search for Related Content