|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 6. Dll3 and Psen1 can act independently of each other in regulation of the
caudal genes. The stripe pattern of Dll1 and Uncx4.1 is
correlated with the skeletal morphology of the vertebrae (A,F,K). In the
Dll3pu/pu embryo, the blurred and randomized expression of
Dll1 and Uncx4.1 results in disorganized skeletal elements
(B,G,L). In the Psen1-null embryo
(Dll3+/+Psen1-/-), stripes of
Dll1 and Uncx4.1 expression, and the pedicles were
completely lost (C,H,M). Weak disorganized expression of Uncx4.1 was
observed in the Dll3/Psen1 double-null embryo
(Dll3pu/puPsen1-/-; D,I). The vertebrae of
Dll3pu/puPsen1-/- exhibited an intermediate
morphology between Dll3-null and Psen1-null vertebrae (N). Surprisingly, the
Dll3+/puPsen1-/- embryo exhibited faint stripes
of Dll1 (E, arrowheads) and Uncx4.1 (J), and a small amount
of skeletal elements (O, arrowheads).
|
