Fig. 2. Molecular structure of Wise. (A) Alignment of the predicted amino acid sequence of Zebrafish, Xenopus, chick, mouse and human Wise proteins. Shaded boxes represent identical amino acids between species; thick line underneath shows conserved amino acids in SOST, asterisks indicate residues conserved in Drosophila Slit and dots identify residues conserved in Cef10 (chick homologue of Cyr61 in CCN family). Circles mark conserved cysteine residues. The arrowhead delineates the site of signal peptide cleavage predicted in the chick protein. (B) Diagram showing alignment of conserved amino acids between Wise, Cef10 and Drosophila Slit. Red filled ovals and lines indicate cysteine residues conserved between Wise, Cef10 and Slit. Open ovals indicate additional cysteines in Cef10 conserved in the CT domain of CCN family members but not in Wise or Slit. Black dotted lines show other conserved amino acids.

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