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First published online August 18, 2003

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Development 130, e1904 (2003)
Copyright © 2003 The Company of Biologists Limited

IN THIS ISSUE

Meox1 and Meox2: a somitogenic double act


In vertebrates, the formation of somites - epithelial blocks of cells that bud off in a temporally and spatially coordinated manner from the unsegmented presomitic mesoderm - precedes the correct development of the axial skeleton, skeletal muscles and dermis. On p. 4655, Mankoo et al. report that the concerted action of the homeobox genes Meox1 and Meox2 regulates several genetic pathways that are involved in somite formation, patterning and differentiation. Mice lacking Meox1 activity had defects in their vertebrae and ribs, whereas mice lacking Meox2 activity showed defective differentiation and morphogenesis of the limb muscles. Mice deficient for both genes lacked an axial skeleton and had severely deficient skeletal muscles. This unexpectedly severe phenotype indicates that Meox1 and Meox2 are both required for somite epithelialisation, patterning and boundary maintenance, as well as for the normal differentiation of both sclerotome- and dermomyotome-derived cells.


Related articles in Development:

The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites
Baljinder S. Mankoo, Susan Skuntz, Ian Harrigan, Elena Grigorieva, Al Candia, Christopher V. E. Wright, Heinz Arnheiter, and Vassilis Pachnis
Development 2003 130: 4655-4664. [Abstract] [Full Text]  




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