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First published online August 18, 2003

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Why some mice have white belts

The study of white-spotting mouse mutations, which create distinct pigment patterns by affecting the maturation and survival of the neural crest-derived melanoblasts, has helped to elucidate the developmental mechanisms required for lineage determination, migration and proliferation. On p. 4665, Rao et al. reveal that Adamts20, a novel member of the ADAMTS family of secreted metalloproteinases, is mutated in belted (bt) mutant mice. These mutants are normally pigmented apart from a 'white belt' of hair that occurs near their hindlimbs. The researchers show that Adamts20 is not expressed by the neural crest-derived melanoblasts but by the mesenchymal tissue through which these cells migrate. The extensive homology between Adamts20 and GON-1, an ADAMTS family member protease that is required for distal tip cell migration in C. elegans, indicates that the role of secreted metalloproteinases in cell migration has been conserved during evolution.

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A defect in a novel ADAMTS family member is the cause of the belted white-spotting mutation

Cherie Rao, Dorothee Foernzler, Stacie K. Loftus, Shanming Liu, John D. McPherson, Katherine A. Jungers, Suneel S. Apte, William J. Pavan, and David R. Beier
Development 2003 130: 4665-4672. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?