Fig. 1. Embryonic expression pattern of LPP genes. LPP1 in situ hybridization in an E9.5 embryo (left sense, right antisense) with a uniform ubiquitous expression (purple color). (B) LPP2 in situ hybridization in an E9.5 embryo (left sense, right antisense). LPP2 is weakly but still widely expressed (purple color). (C-K) LPP3 expression in LPP3-IRESlacZ embryos as revealed by ß-galactosidase staining (blue). (C,D) E6.5 embryos showing expression in the extra-embryonic ectoderm (Ex). (E,F) In E7.5 embryos LPP3 is expressed in the anterior (a) domain of the embryo and extra-embryonic membranes. (E) lateral and (F) frontal views. ve, visceral endoderm; ch, chorion. (G,H) E8.0 embryo showing expression of LPP3 in (G) the chorion and anterior domain of the embryo and (H) around (arrows) the node (n) and in the tip of the allantois (all). (I) E8.5 embryo showing strong LPP3 expression in the allantois (all) and paraxial mesoderm. (J) E9.5 embryo showing expression in the somites (s), developing gut (^*) and the chorio-allantoic placenta (p). (K) E10.5 embryo showing LPP3 expression in the limb with strongest expression in the apical ectodermal ridge (AER) and continued expression in the umbilical cord (u).

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