Fig. 2. Skeletal muscle abnormalities in Meox double mutants. Transverse paraffin wax-embedded sections of control (A,B) and mutant (C,D) foetuses at E16.5, at the level of the tongue (A,C) and forelimbs (B,D) demonstrating that most skeletal muscles are absent or reduced in size in the mutant. These include: the prevertebral muscles of the neck (black arrowhead in A and C), the epaxial (black arrow) muscles of the trunk and also the hypaxial muscles of the trunk including those of the abdominal wall (white arrows) and intercostal muscles (white arrowhead). The brown fat overlying the shoulder muscles in control foetuses (* in B) was also absent in mutants. t, tongue; l, lung; h, heart.

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