Fig. 6. The cerebellar phenotype of MBP-TK mice is dependent on oligodendrocyte ablation timing. Cerebella of 3-week-old wild-type (A,E) and MBP-TK (B-D,F-H) mice treated with three different FIAU injection protocols (1-20d: A,B,E,F; 1-6d: C,G; 6-20d: D,H) were used for double immunostaining with anti-calbindin (green) and anti-parvalbumin (red) antibodies (A-D), and histological analysis of Cresyl Violet stained sections (E-H). Parvalbumin-positive interneurons are indicated by arrowheads (A-D). ML, molecular layer; IGL, internal granular layer; WM, white matter. Scale bars: 25 µm (A-D); 50 µm (E-H).

Return to article