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Fig. 4. Spatial reversal of innervation patterns during postnatal development in
TrkB and Bdnf mutants. Representative images of sections through the cochlear
turns at the indicated levels (apical/medial/midbasal/basal) of animals with
the indicated genotypes, labelled with anti-NF200 antibodies as described
under Materials and methods. Arrows point to the level of the three rows of
outer hair cells (OHC) and the single row of inner hair cells (IHC). The open
arrows mark the position of afferent fibres innervating OHCs. Note the absence
of NF200-positive fibres below OHCs in the apical and medial cochlear turns of
TrkBshc/-, Bdnf-/- or
TrkB-/- mutants compared with
TrkBshc/+ control animals during the first
postnatal week (A). Sections through basal and midbasal cochlear turns of
adult TrkBshc/- and P19
Bdnf-/- mice lack afferent innervation to OHCs, compared
with their respective age-matched controls, shown for
TrkBshc/+ (B). Scale bars: 20 µm.
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