Fig. 4. C3G^gt/gt mutant phenotype. Homozygous mutant embryos at E11.5 (A-C), E13.5 (D,E), E14.5 (F, dead), and (G-I) Haematoxylin and Eosinstained paraffin sections at E11.5. Note the formation of haemorrhages in the majority of cases (E10.5-E11.5), which initiated near the hindbrain neuroepithelium (arrows in A,B,G). These haemorrhages enlarged (H) and finally the neuroepithelium ruptured (arrow in I). In other cases, embryos exhibited massive subcutaneous oedema and haemorrhagic oedema at E13.5 (arrows in D,E). Bar represents 77 µm in A-C, 150 µm in D,E, 190 µm in F, 106 µm in G, 66 µm in H and 80 µm in I.

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