Fig. 5. Elastin therapy reduces vascular smooth muscle cell accumulation and arterial obstruction in vivo. (A) Scanning electron micrographs of elastin sheaths. Scale bar: 10 µm. (B) Elastin matrix sheath covering an expanded metal stent. (C,D) Representative cross-sections taken from control arteries (n=14) display the development of a thick fibrocellular neointima (C), whereas the neointima is substantially decreased in elastin sheath (arrows) treated arteries (n=13) with the same injury score (D). (E,F) Over a range of injury, the percent lumen stenosis (E) and mean neointimal thickness (F) were significantly reduced (both P<0.0001) in injured porcine coronary arteries treated with elastin sheath-stents compared with control stents.

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