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First published online September 2, 2003

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Giving a helping hand to chordin

The tight temporal and spatial regulation of signalling by the secreted bone morphogenetic proteins (BMPs) is essential for patterning the dorsal-ventral axis of vertebrate embryos. Now Blitz et al. provide further details of how BMP activity is regulated during early Xenopus embryogenesis and, in particular, show that the secreted protein twisted gastrulation (TSG) is a BMP inhibitor (see p. 4975). In their experiments, reducing TSG expression with antisense morpholino oligonucleotides caused moderate head defects that could be rescued by chordin, a BMP antagonist that is produced by the Spemann's organiser. The simultaneous downregulation of TSG and chordin produced stronger BMP inhibition than did downregulating either TSG or chordin alone. Blitz and co-workers conclude that, by acting together to inhibit BMP signalling, TSG and chordin cooperate to regulate dorsal cell fates during early frog development.

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Related articles in Development:

Twisted gastrulation loss-of-function analyses support its role as a BMP inhibitor during early Xenopus embryogenesis

Ira L. Blitz, Ken W. Y. Cho, and Chenbei Chang
Development 2003 130: 4975-4988. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?