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First published online September 2, 2003

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Development 130, e2003 (2003)
Copyright © 2003 The Company of Biologists Limited

IN THIS ISSUE

Role for Notch in kidney development


Although the Notch signalling pathway has been previously implicated in mammalian kidney development, its precise role in this organ's development has remained unclear because mice with disrupted Notch signalling die before the kidney develops. On p. 5031, Cheng et al. circumvent this problem by treating mouse organ kidney cultures with an inhibitor of {gamma}-secretase, the enzyme that is required for Notch activation. The mesenchyme-to-epithelium transition occurred as normal in these cultures, but podocytes and proximal tubules failed to form from the renal vesicle where activated Notch is normally detected. Mice null for the presenilins Psen1 and Psen2 also lack {gamma}-secretase activity, and, on p. 5019, Wang et al. report that Psen1/Psen2 double-null mutants have similar kidney defects to those seen by Cheng et al. To make these experiments possible, the double-null mice were rescued from early embryonic lethality by the restricted expression of a human PSEN1 transgene. In a third paper on Notch, Sasamura and co-workers report that, in Drosophila, the O-fucosylation of Notch is essential for its interaction with its receptor, Delta, and suggest that this modification could be a widespread regulatory mechanism in signal-transduction systems (see p. 4785).


Related articles in Development:

neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions
Takeshi Sasamura, Nobuo Sasaki, Fumiyasu Miyashita, Shiho Nakao, Hiroyuki O. Ishikawa, Mikiko Ito, Motoo Kitagawa, Kenichi Harigaya, Eric Spana, David Bilder, Norbert Perrimon, and Kenji Matsuno
Development 2003 130: 4785-4795. [Abstract] [Full Text]  

Presenilins are required for the formation of comma- and S-shaped bodies during nephrogenesis
Pei Wang, Fred A. Pereira, Duane Beasley, and Hui Zheng
Development 2003 130: 5019-5029. [Abstract] [Full Text]  

{gamma}-Secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney
Hui-Teng Cheng, Jeffrey H. Miner, MeeiHua Lin, Malú G. Tansey, Kevin Roth, and Raphael Kopan
Development 2003 130: 5031-5042. [Abstract] [Full Text]  




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