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Fig. 3. Histological analysis of pancreatic tissue at E18.5. Hematoxylin/Eosin
(A,B) and amylase (red; C,D) staining of E18.5 pancreatic tissue shows normal
exocrine architecture in Hhip–/– (Hip1 in
figure; B,D). By contrast, clustering (A,B; broken yellow lines) and size of
islets as shown by insulin staining (green; C,D) is impaired in
Hhip–/– embryos (B,D). Expression of smooth
muscle actin is confined to blood vessels in mutants and wild type (E,F),
indicating that loss of Hhip function does not lead to transformation of
pancreatic mesenchyme into duodenal mesoderm.
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