spacer gif spacer gif spacer gif spacer gif ARCHIVE ANNOUNCEMENT! spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

First published online September 15, 2003

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content
Development 130, e2101 (2003)
Copyright © 2003 The Company of Biologists Limited

IN THIS ISSUE

Xrx1: proliferation in the neural plate


Posterior cells of the Xenopus neural plate undergo neurogenesis at the end of gastrulation, whereas cells of the anterior region continue to proliferate and differentiate at a later stage. Unlike posterior neurogenesis, the factors that regulate proliferation and differentiation of the anterior neuroectoderm are poorly understood. Now, on p. 5143, Andreazzoli and coworkers report that the homeobox gene Xrx1, which functions during eye and anterior brain development, is a crucial regulator of the balance between proliferation and neurogenesis of the anterior neuroectoderm. Activated by chordin and hedgehog signalling, Xrx1 is expressed over the whole anterior neural plate and promotes proliferation by repressing the cell-cycle inhibitor p27Xic1. Xrx1 also activates two anti-neurogenic transcription factors, Xhairy2 and Zic2, and, in so doing, represses several genes associated with neurogenesis.


Related articles in Development:

Xrx1 controls proliferation and neurogenesis in Xenopus anterior neural plate
Massimiliano Andreazzoli, Gaia Gestri, Federico Cremisi, Simona Casarosa, Igor B. Dawid, and Giuseppina Barsacchi
Development 2003 130: 5143-5155. [Abstract] [Full Text]  




This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Related articles in Development
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Search for Related Content