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First published online September 15, 2003

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Recycling developmental tools during regeneration

Han et al. shed new light on the interplay between mechanisms of development and of regeneration (see p. 5123). The genes Msx1 and Msx2 are implicated in early development of the mouse limb, but their roles during limb regeneration have not previously been characterised. Ken Muneoka's lab has shown before that Msx1 is expressed during digit tip regeneration in fetal and neonatal mice, and, by using Msx1 mutants, they now demonstrate that Msx1 is required for this regeneration response. Using a novel in vitro system, they demonstrate that exogenous Bmp4, a protein essential for digit regeneration, rescues the Msx1 mutant phenotype. They also report that endogenous Bmp4 is regulated by the combined activities of Msx1 and Msx2, and that this regulation may be mediated by the transcriptional regulator Runx2.

Related articles in Development:

Digit regeneration is regulated by Msx1 and BMP4 in fetal mice

Manjong Han, Xiaodong Yang, Jennifer E. Farrington, and Ken Muneoka
Development 2003 130: 5123-5132. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content