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First published online September 15, 2003

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macho-1 mesenchyme in ascidian embryos

Conserved signalling pathways can induce different outcomes in different developmental contexts. In the ascidian vegetal hemisphere, notochord and mesenchyme are induced in the anterior and posterior margins, respectively, by the same fibroblast growth factor (FGF). To become mesenchyme, the posterior blastomeres must inherit posterior-vegetal cytoplasm from the egg. Kobayashi and co-workers used gain- and loss-of-function experiments to demonstrate that the action of the posterior-vegetal egg cytoplasm is due to maternal mRNA encoding the putative transcription factor and muscle determinant Macho-1 (see p. 5179). Expression of macho-1 is both necessary and sufficient to determine the mesenchymal fate of the posterior vegetal hemisphere; in its absence, notochord is induced. Kobayashi et al. suggest that Macho-1 acts upstream of the transcriptional repressor Snail, which suppresses notochord induction by suppressing the transcription factor Brachury.

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Related articles in Development:

Maternal macho-1 is an intrinsic factor that makes cell response to the same FGF signal differ between mesenchyme and notochord induction in ascidian embryos

Kenji Kobayashi, Kaichiro Sawada, Hiroki Yamamoto, Shuichi Wada, Hidetoshi Saiga, and Hiroki Nishida
Development 2003 130: 5179-5190. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?