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First published online September 15, 2003

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Enhancer swaps in fly and worm

Several developmental genes display remarkably conserved expression patterns between distantly related organisms. Little is known about the conservation of mechanisms that control gene expression, but it is perhaps surprising that enhancer sequences diverge relatively rapidly. On p. 5133, Ruvinsky and Ruvkun test whether enhancers from the fly can drive expression in homologous cell types in the worm. Approximately 90% of fly enhancers are unable to function in the worm, indicating that the binding sites of fly enhancer sequences and worm transcription factors have diverged too far for proper recognition to take place. The authors suggest that expression patterns are not conserved by preserving enhancer function, but by co-evolution among members of transcription initiation complexes, thus preserving the cohesive interactions between enhancers and their binding factors.

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Related articles in Development:

Functional tests of enhancer conservation between distantly related species

Ilya Ruvinsky and Gary Ruvkun
Development 2003 130: 5133-5142. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?