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First published online September 15, 2003

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Flow dynamics and genetic determinism

Several known genes are crucial for blood vessel growth and differentiation but the cues that shape the architecture of the vascular system are still unclear. On p. 5281, Isogai and colleagues examine the influence of blood flow dynamics on the patterning of blood vessels that develop in the vertebrate trunk. Following observations of zebrafish embryos that express green fluorescent protein throughout the vascular network, the authors describe a two-step process of angiogenesis in which primary sprouts emerge from the dorsal aorta and secondary sprouts arise from the posterior cardinal vein. The authors used silent heart mutant embryos, which have hearts that do not beat, to show that circulatory flow dynamics do not affect the development of the primary network and have little influence on the patterning of the secondary network. Importantly however, their results support the idea that circulatory flow does affect the patterning of interconnections between the primary and the secondary networks, consistent with the notion that the architecture of the vascular system is orchestrated by the interplay between `hard-wired' anatomy and flow dynamics.

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Angiogenic network formation in the developing vertebrate trunk

Sumio Isogai, Nathan D. Lawson, Saioa Torrealday, Masaharu Horiguchi, and Brant M. Weinstein
Development 2003 130: 5281-5290. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?