Fig. 5. Consequences of Myc activation in the epidermis of K14MycER transgenic mice. Transgenic mice and nontransgenic (wild-type) littermates were injected with BrdU according to the LRC protocol. After a 70 day chase period, wholemounts of tail epidermis were examined immediately (no OHT) or after daily treatment with 4-hydroxy-tamoxifen (OHT) for the number of days shown. Epidermis was labelled to detect keratin 14 (red) and Nile Red (green) (A,D,G,J,M), keratin 14 (red) and BrdU (green) (B,E,H,K,N), or Ki67 (red) and BrdU (green) (C,F,I,L,O). Arrows (G,J) indicate individual or clusters of sebocytes located in the interfollicular epidermis. Scale bar: 100 µm.

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