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First published online October 6, 2003

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Navigating the maze of brain development

To ensure that the correct pattern of neuronal connections is achieved during brain development, axonal outgrowth is controlled both by adhesion to early outgrowing axons (pioneers) and by a number of different extracellular signals. On p. 5307, Harald Hutter describes how, in the ventral cord of C. elegans, different groups of axons in the same axon bundle use different combinations of these guidance cues to navigate. For his experiments, Hutter generated transgenic worms in which different GFP markers were expressed in subsets of neurons with axons in the ventral cord. He then examined the trajectories of individual axons after laser ablation of specific pioneer neurons. His results indicate that axons within the ventral cord navigate largely independently of each other, and that some axons can find their way in the absence of pioneer neurons.

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Related articles in Development:

Extracellular cues and pioneers act together to guide axons in the ventral cord of C. elegans

Harald Hutter
Development 2003 130: 5307-5318. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?