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First published online October 6, 2003

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Divide and rule: combinatory control of Hox domains

Although Hox genes are expressed over broad domains, they control cell diversification and patterning in very localised regions within their expression domains. In a study on midgut morphogenesis in Drosophila, Grienenberger et al. describe how cell-type specificity and diversity is conferred on the activity of the Hox protein Abdominal A (AbdA) by Decapentaplegic (Dpp)/Tgfß signalling (see p. 5445). They identify a new enhancer region in the wingless (wg) gene, and show that AbdA can only induce wg transcription in the presence of Mad, a transcriptional effector of the Dpp pathway. Dpp is secreted by parasegment 7 (PS7) of the embryonic midgut, and thus, although AbdA is expressed and active in parasegments PS8 to PS12, wg transcription is limited to PS8 because it is only here that Hox function and Dpp signalling converge.

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Tgfß signaling acts on a Hox response element to confer specificity and diversity to Hox protein function

Aurélie Grienenberger, Samir Merabet, John Manak, Isabelle Iltis, Aurélie Fabre, Hélène Bérenger, Matthew P. Scott, Jacques Pradel, and Yacine Graba
Development 2003 130: 5445-5455. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?