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Fig. 1. Loss of Hh signaling disrupts DRG development. Confocal stacks of lateral views of embryos processed for anti-Hu at 60 hpf. (A) Normal pattern of DRG neurons (arrowheads) in wild-type (WT) embryos. (B) syu mutants lack DRG in many segments (asterisks), but abnormal clusters of neuronal cells (arrows) also appear. (C) WT embryos treated with 6.0 µg/ml of cyclopamine during gastrulation show similar phenotypes.





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