Fig. 4. The severity of the DRG defects corresponds to the level of Hh signaling. Graphs show the percentage of normal DRG neurons, missing DRG neurons (zero) and abnormal neuronal clusters (large) for yot, con, dtr, smu and syu mutant embryos. The bottom graphs show DRG phenotypes from embryos that were treated starting at dome stage with the concentration of cyclopamine indicated. Embryos were fixed and processed for anti-Hu immunoreactivity at 60 hpf.

Return to article