Fig. 8. Model for the role of Egfr/Ras signaling in the context of ommatidial rotation. Raf/MAPK nuclear signaling to Pnt upregulates the transcription of activating (spi) and inhibiting (aos) Egfr ligands and might regulate transcription of additional genes important for ommatidial rotation. Egfr/Ras signal via Canoe to affect cytoskeletal and/or cell junctional elements (junctions are schematized as black oval regions on membrane). In addition, Egfr signaling affects Flamingo localization (the effector regulating this aspect is not known).

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