Fig. 3. Evolutionary conservation of the wg midgut enhancer. (A,B) Enhancer activities visualized by in situ hybridization to lacZ transcripts. Embryos are shown in a lateral view. The D. virilis counterpart of the XC enhancer drives expression in the central part of the midgut (B), as does the D. melanogaster XC enhancer (A), although at a reduced level. (C) Alignment of the D. melanogaster (mel), D. pseudoobscura (pseu) and D. virilis (vir) sequences. Sequences in red emphasize sequence identity. Two long stretches of sequence conservation are boxed in yellow. Consensus binding sites are indicated in blue for Hox and Hox/Pbx complexes, and in green for Mad/Medea (referred to as DRS) and Creb proteins. Sequences after the arrow are deleted in XC([Hox/Pbx2-3-4]).

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