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First published online October 22, 2003

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Development 130, e2301 (2003)
Copyright © 2003 The Company of Biologists Limited

IN THIS ISSUE

Setting the boundaries: segmentation in Drosophila


For patterning and growth to occur in well-defined embryonic regions during development, boundaries need to be established between groups of cells. On p. 5625, Larsen et al. report that both Hedgehog signalling and Engrailed expression play distinct roles in promoting the morphological changes associated with the formation of epidermal segment boundaries in Drosophila embryos. These boundaries, which are visible as deep grooves in the epidermis, form at the posterior edges of stripes of engrailed expression. The researchers describe how engrailed-expressing cells at the boundary undergo apical constriction, move inwards and become bottle shaped. The results of genetic analyses reveal that for these events to occur, Hedgehog signalling and Engrailed expression are needed at the posterior and anterior, respectively, of each boundary, and that Wingless signalling at the anterior of the segments prevents boundary duplication.


Related articles in Development:

Segment boundary formation in Drosophila embryos
Camilla W. Larsen, Elizabeth Hirst, Cyrille Alexandre, and Jean-Paul Vincent
Development 2003 130: 5625-5635. [Abstract] [Full Text]  




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