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First published online October 22, 2003

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Initiation of handedness in C. elegans

In most animals, the placement of the internal organs has left-right (LR) asymmetry with an invariant handedness. How handedness – whether an organ lies on the right or the left – is initiated during development is unclear. On p. 5731, Bergmann and co-workers identify GPA-16, a component of a heterotrimeric G protein, as the first C. elegans protein that affects handedness. LR asymmetry in C. elegans becomes evident sometime between the four- and six-cell stages, and is determined by a shift in the orientation of specific mitotic spindles. The researchers show that loss-of-function of GPA-16 affects spindle orientations during the third cleavage and nearly randomises handedness among the resulting adult worms. Heterotrimeric G proteins are also involved in the control of asymmetric cell division, and on p. 5717, Tsou et al. show that G-protein signalling interacts with LET-99, a protein whose localisation pattern is dependent on polarity cues, to regulate spindle orientation, and thus asymmetric cell division, in early C. elegans embryos.

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LET-99 opposes G/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling

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Development 2003 130: 5717-5730. [Abstract] [Full Text]  

Embryonic handedness choice in C. elegans involves the G protein GPA-16

Dominique C. Bergmann, Monica Lee, Barbara Robertson, Meng-Fu B. Tsou, Lesilee S. Rose, and William B. Wood
Development 2003 130: 5731-5740. [Abstract] [Full Text]  

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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?