Fig. 5. Roles of bon and sur in hatching gland, heart and nervous system development. Wild-type (A,E,I), bonMO (B,F,J) MZsur (C,G,K), MZsur;bonMO (D,H,L) embryos at 5S (A-D), 20S (E-H) and 18S (I-L) stages. (A-D) Dorsal view of islet-1 expression in developing hatching gland (arrow). (E-H) Ventral view of cardiac myosin light chain 2 (cmlc2) expression in a single domain in wild-type (E), in two domains in bonMO (F), in a single domain in MZsur (G) but not in MZsur;bonMO (H). Lateral view, anterior to the left, dorsal up, of nk2.2 expression in ventral neuroectoderm; normal expression in wild-type (I) and bonMO (J), reduced anterior expression in MZsur (arrow in K), and lack of expression in MZsur;bonMO (L).

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