Fig. 8. Bax inactivation could prolong the survival of ectopic nuclei. (A-D) Ventricular views of Isl1 expression in wild-type (A), Bax (B), Hoxb1 (C) and Hoxb1/Bax (D) flat-mounted mutant hindbrains at 14.5 dpc. In both wild-type and Bax mutants, the Vm, VIm and VIIm could be detected (A,B, black arrows). In Hoxb1 mutants only the Vm and VIm could be detected (C, black arrowheads), whereas the VIIm was absent (C, white arrowheads). In Hoxb1/Bax mutants, the Vm and the VIm could be detected (D, black arrowheads), but not the VIIm (D, white arrowheads). In Bax and Hoxb1/Bax mutants there was an additional ventral column of ectopic Isl1-positive cells in the caudal hindbrain (B,D, asterisks).

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